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ooli3@sopuli.xyzM to GetBetter@sopuli.xyz · 2 months ago

Scientists found that the creatine supplement millions take for muscle gains is quietly raising brain energy levels and slowing early Alzheimer's cognitive decline by 30% - thesciverse

thesciverse.org

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Scientists found that the creatine supplement millions take for muscle gains is quietly raising brain energy levels and slowing early Alzheimer's cognitive decline by 30% - thesciverse

thesciverse.org

ooli3@sopuli.xyzM to GetBetter@sopuli.xyz · 2 months ago
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Tens of millions of people take creatine every day for their muscles. A comprehensive review and a landmark clinical trial published in 2025 and 2026 have now documented what the same supplement is quietly doing to their brains. Creatine crosses the blood-brain barrier, raises phosphocreatine levels in neurons, and provides the ATP buffer that keeps cognitive performance from hitting an energy ceiling during demanding mental work. In early Alzheimer's patients, it slowed cognitive decline by approximately 30% versus placebo in a controlled trial. In healthy adults under sleep deprivation, a single dose measurably improved cognitive performance. In depression patients, adding it to cognitive behavioral therapy significantly improved outcomes beyond therapy alone. None of this is mentioned on the label.
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  • Dr. Bob@lemmy.ca
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    2 months ago

    This is a nothing-burger. The “comprehensive review” is in fact a mini-review. The pilot was 20 patients in a single arm study - there was no active or passive controls and neither the patients or their caregivers were blind to the intervention. And the meta review?

    • SaveTheTuaHawk@lemmy.ca
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      2 months ago

      There is so much garbage in Alzheimer research it’s not funny.

    • Tattorack@lemmy.world
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      2 months ago

      About what I expected. Few headlines like these are worth a damn.

    • kodevade@lemmy.zip
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      2 months ago

      For someone who just read the headlines and up voted(not proud, not guilty either) the post, thanks for the comment.

  • Crackhappy@lemmy.world
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    2 months ago

    Son of a bitch. I hate the taste of creatine, but am at a very high risk of Alzheimers.

    • Brokkr@lemmy.world
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      2 months ago

      Pure creatine is nearly flavorless. You can also mix it with other flavored drinks.

      • makeshift0546@lemmy.today
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        2 months ago

        100% wrong. Good lord confidentiality incorrect.

        • Brokkr@lemmy.world
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          2 months ago

          I’ve never been able to taste it and searching reveals that pure creatine monohydrate is most likely tasteless. However, some people describe it as slightly sour. However, my experience and that of most people that I’m seeing online report it as being easily masked by coffee, tea, or protein shakes.

          Also, I think you meant confidently. I only mention it because it seems like the details matter to you.

      • Crackhappy@lemmy.world
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        2 months ago

        That’s not at all my experience. I’ve tried so many different versions and it’s a very strong flavor to me.

        • shaoiken@feddit.org
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          2 months ago

          It’s more expensive but you can get it in capsules to swallow.

      • fake@sh.itjust.works
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        2 months ago

        Yea, just has the texture of sand.

        • Brokkr@lemmy.world
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          2 months ago

          It dissolves slowly in cold water. If you take it, you could try mixing with hot coffee or tea.

  • SpruceBringsteen@lemmy.world
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    2 months ago

    Also helps with one of the most important factors in aging gracefully: retaining muscle mass.

    • skhayfa@lemmy.world
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      2 months ago

      Not that straightforward https://www.zmescience.com/science/news-science/creatine-gains-no-gym/

  • terranoid@lemmy.cafe
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    2 months ago

    Creatine made my stock portfolio go up 45%

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