Armoring CAR T cells to prevent self-sabotage and better fight cancer

penntoday.upenn.edu

Armoring CAR T cells to prevent self-sabotage and better fight cancer

penntoday.upenn.edu

Daryl76679@lemmy.ml to

Medicine@mander.xyz · 6 days ago

Armoring CAR T cells to prevent self-sabotage and better fight cancer | Penn Today

penntoday.upenn.edu

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

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