Domesticated animals play a prominent role in our society, with two-thirds of American families enjoying the companionship of pets and many others relying on animal products for their nutritional needs. But the process of domestication remains a bit of a mystery. Convincing wild animals they are safe enough to coexist and mate in enclosures and in close proximity to humans and other animals is no small feat. What does it take behaviorally and genetically for that to happen?